In this introductory review, we will delineate mechanisms of DNA damage and the counteracting repair/tolerance pathways to provide insights into the molecular basis of genotoxicity in cells …

DNA damage can occur naturally or via environmental factors, but is distinctly different from mutation, although both are types of error in DNA. DNA damage is an abnormal chemical …

Sep 8, 2023 · DNA is the basic unit of inheritance that maintains the integrity and function of living organisms. However, it is constantly exposed to damaging agents which can cause DNA …

Mar 17, 2025 · This Review discusses the molecular mechanisms of end resection and its regulation, focusing on the roles of post-translational modifications throughout the cell cycle …

Aug 3, 2025 · Ultraviolet rays from the sun, harmful chemicals in the environment, by-products of metabolism, and even errors during cell division can all cause DNA damage. It’s estimated …

The page provides an extensive overview of DNA mutations and repair mechanisms, aimed at biochemistry majors. It covers types and causes of DNA mutations, mechanisms of DNA …

Mutations are random changes that occur within the sequence of bases in DNA. They can be large scale, altering the structure of the chromosomes, or small scale where they only alter a …

DNA damage occurs continuously as a result of various factors—intracellular metabolism, replication, and exposure to genotoxic agents, such as ionizing radiation and chemotherapy. If …

Oct 20, 2023 · DNA damage refers to abnormalities and lesions in the DNA molecule resulting from exposure to endogenous and environmental agents. These alterations interfere with DNA …

In the first part of this review, we describe the critical processes encompassing DNA damage sensing and resolution. In the second part, we illustrate the consequences of partial or …

Unfortunately, the cell is exposed all the time to both endogenous, and exogenous or environmental factors that can damage the DNA. Luckily, if DNA gets damaged, the cell can …

DNA is essential to life, but it is subject to damage from interaction with various chemicals and environmental agents. In addition, mutations arise each time DNA is replicated.

But if the DNA damage occurs to a gene that makes a DNA repair protein, a cell has less ability to repair itself. So errors will build up in other genes over time and allow a cancer to form. …

Jan 24, 2024 · The review addresses key questions, including the major types of DNA damage, common DNA repair mechanisms, the availability of reliable databases for DNA damage and …

6 days ago · The study uncovers how hair pigment stem cells, under DNA damage, make fate decisions—leading to graying or melanoma Hair graying and melanoma—a form of skin …

DNA damage occurs continuously as a result of various factors—intracellular metabolism, replication, and exposure to genotoxic agents, such as ionizing radiation and chemotherapy. If …

Much of the current research in the DNA damage field is devoted towards understanding the mechanisms and biological implications of DNA lesions that turn into genetic mutations; …

Aug 14, 2023 · So these are a few examples of the kinds of damage that can occur in DNA, and while there are many more most of them fall into one of these categories according to the type …

In the review here, we discuss several genetic disorders linked to DNA repair defects, attempting to draw correlations between the nature of the accumulating DNA damage and the …

Jan 5, 2024 · To aid researchers in understanding the underlying mechanisms of genome instability, a number of genome-wide profiling approaches have been developed to monitor …

Chemotherapeutics target rapidly dividing cancer cells by directly or indirectly inducing DNA damage. Upon recognizing DNA damage, cells initiate a variety of signaling pathways …

Jan 16, 2024 · Over the past decade, substantial progress and pivotal discoveries have been achieved in DNA damage and repair. This comprehensive review paper consolidates research …

Jul 9, 2021 · Genomic instability is the hallmark of various cancers with the increasing accumulation of DNA damage. The application of radiotherapy and chemotherapy in cancer …

Can sun damage be reversed? Once UV radiation changes your skin cells’ DNA, the DNA damage can’t be reversed. However, this doesn’t mean that you can’t change the appearance …

Deoxyribonucleic acid (pronunciation ⓘ [1]; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic …

2 days ago · This DNA damage is a well-known factor in the development of aging and cancer, yet scientists have long struggled to understand the exact link -- especially how DNA-damaged …

DNA damage is the central mechanism through which changes in the genome occur.