A new editorial paper was published in Oncoscience (Volume 10) on November 14, 2023, entitled, "Be mindful of potential pitfalls when using the Cre-LoxP system in cancer research." In this new ...

Cre-loxP, a powerful tool for preclinical cancer research, possesses intrinsic pitfalls that can alter result accuracy, according to an editorial paper in Oncoscience. Cancer and other diseases could ...

To discover the function of a gene researchers turn it off and observe the consequences. Often genes have multiple functions that differ depending on a tissue and age. Some genes are essential to ...

Scientists of the National Center for Cardiovascular Research (CNIC) led by Rui Benedito have developed a new genetic tool (iSuRe-Cre) that provides certainty in Cre-inducible genetic modifications, a ...

We have created a stable transgenic rag2-EGFP-mMyc zebrafish line that develops GFP-labeled T cell acute lymphoblastic leukemia (T-ALL), allowing visualization of the onset and spread of this disease.

Mice with inducible reporter genes allow systemic profiling of gene expression throughout the brain. Researchers led by Hongkui Zeng at the Allen Brain Institute have created and characterized ...

Researchers design a Cas9 enzyme that cuts DNA only in the presence of particular drug. A series of rodent experiments showed that even with abundant food and water, personal space is essential to ...

A team of Chinese researchers has developed two new genome editing technologies, known collectively as Programmable Chromosome Engineering (PCE) systems. The study, published online in Cell on August ...

A team of scientists at the Centro Nacional de Investigaciones Cardiovasculares (CNIC) led by Rui Benedito has generated a novel genetic tool, called iSuRe-HadCre, that enables the induction of ...

(Nanowerk News) A team of Chinese researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology of the Chinese Academy of Sciences has developed two new genome editing ...